The short version
The short version of this review
La Roche-Posay Retinol B3 Serum, labelled 0.3% Retinol + Vitamin B3 Serum in the UK, combines 0.3% retinol with niacinamide, retinyl palmitate and hyaluronic acid. The brand directs evening use once or twice a week at first, building towards nightly, with SPF by day. It was £48 for 30ml at LOOKFANTASTIC on 25 September 2026.
Product information reviewed 2026-09-25.
01 / The basics
What is 0.3% Retinol + Vitamin B3 Serum?
La Roche-Posay UK labels this serum 0.3% retinol with niacinamide (vitamin B3), retinyl palmitate and glycerin; the brand directs evening use once or twice a week at first, building towards nightly, with SPF in the morning. The ingredient list includes fragrance and denatured alcohol.
- Best for
- A measured first retinol routine
02 / Review
What is in 0.3% Retinol + Vitamin B3 Serum?
La Roche-Posay’s Retinol B3 Serum, labelled in the UK as 0.3% Retinol + Vitamin B3 Serum, combines retinol at 0.3% with niacinamide, retinyl palmitate and hyaluronic acid in a lightweight dropper serum. The brand positions its range for sensitive skin.
The 0.3% figure also matches the maximum retinol equivalent the EU now allows in most leave-on cosmetics under Regulation (EU) 2024/996. Great Britain had not adopted an equivalent limit when checked in September 2026.
03 / Review
Who is 0.3% Retinol + Vitamin B3 Serum best for?
A first retinol for readers who want a measured strength from a pharmacy skincare brand, with a gradual schedule written into the directions.
04 / Review
What should you check before buying?
It contains fragrance and denatured alcohol — worth weighing if your skin is reactive, despite the sensitive-skin positioning. Use it in the evening only, follow the gradual start and wear SPF every morning. Speak to a pharmacist or GP before using retinoids in pregnancy.
05 / How to use it
How should you use 0.3% Retinol + Vitamin B3 Serum?
- 01Apply three drops in the evening, after cleansing
- 02Use once or twice a week at first, building to five to seven evenings as tolerated
- 03Follow with moisturiser
- 04Use SPF every morning
06 / Quick facts
What should you know before choosing 0.3% Retinol + Vitamin B3 Serum?
- —Labelled 0.3% retinol with niacinamide (vitamin B3); 30ml with dropper
- —Also lists retinyl palmitate, adenosine, glycerin and sodium hyaluronate
- —Contains fragrance (parfum) and denatured alcohol
- —Evening only: three drops, once or twice a week at first, building to five to seven nights
- —SPF every morning while using retinol
- —£48 at LOOKFANTASTIC (25 September 2026)